Question: My mum has not yet gotten her C19 vaccine. This is because she is anaphylactic allergic to bees (almost died once). I know CDC etc recommendations are still to get the shot, just be monitored in a hospital setting afterwards just in case. However, her new doctor told her not to get it because of the allergy. They moved to Florida not long ago, this is her first time seeing this guy. She went in because her arm swelled up from a spider bite (so similar allergy as the bees). Anyhow, she’s supposed to come out to help us when we move and we really have no one else and she’s being cautious…but I was wondering if there is any data or articles about results of the vaccine on people with a history of anaphylaxis to encourage her. 

Answer:  The CDC, the American College of Allergy, Asthma, and Immunology (ACAAI), the American Academy of Allergy and Clinical Immunology (AAAAI), and the UK’s Healthcare products Regulatory Agency (MHRA), all recommend vaccination for individuals with history of severe allergic reactions not related to previous vaccination and/or not related to ingredients in the vaccines (for more see Q&A of 3/12/21).  These recommendations are based on data from the clinical trials plus surveillance data that has been accumulating with vaccine roll-out.  I think your mom would benefit from talking to another doctor.  
Here are two studies that offer some insight:

1. JAMA, Acute Allergic Reactions to mRNA COVID-19 Vaccines: This prospective cohort study followed 64,900 employees of Mass General Brigham (MGB) who received their first dose of an mRNA vaccine (either Moderna or Pfizer) to understand allergic reactions.  Of those 64,900 individuals, anaphylaxis was confirmed in 16 (0.025%), 15 (94%) of whom were female and 5 (31%) of whom had a history of anaphylaxis.  The authors noted, “Most of the vaccine recipients with anaphylaxis had allergy histories, with 31% having prior anaphylaxis. However, given that approximately 5% of adults have severe food allergy histories and 1% of adults have severe drug allergy histories, this MGB employee cohort likely included almost 4000 individuals with severe food or medication allergy histories who were safely vaccinated.”  My take-away here is that there appears to be some elevated risk for anaphylaxis among individuals with a history of anaphylaxis, but even elevated, the risk is still very small.   
2. JAMA, Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021: This study reviewed Vaccine Adverse Event Reporting System (VAERS) data to understand scope of anaphylaxis post-mRNA vaccine and background characteristics of individuals with anaphylaxis.  Researchers found that during the study period, 66 cases that met the “anaphylaxis” definition/criteria were reported to VAERS.  For comparison, during that same period more than 9.9 million doses of Pfizer and 7.5 million doses of Moderna were administered. Of the 66 cases, 21 (32%) had a history of anaphylaxis.  These findings indicate that there may be a correlation between history of anaphylaxis and experience of anaphylaxis post-vaccination, however, putting this risk into context is important– We’re talking 21 cases with a history of anaphylaxis among millions of doses given.  Based on the prevalence of severe allergies in the general population, we would expect that many thousands of those doses would have gone to individuals with a history of severe allergic reactions.  Again, even if the risk is elevated, it is still low.