{"id":434,"date":"2020-06-11T05:02:00","date_gmt":"2020-06-11T05:02:00","guid":{"rendered":"https:\/\/covidqanda.org\/?p=434"},"modified":"2020-11-09T05:04:31","modified_gmt":"2020-11-09T05:04:31","slug":"is-anyone-collecting-data-on-how-many-of-those-that-survive-are-permanently-injured","status":"publish","type":"post","link":"https:\/\/covidqanda.org\/?p=434","title":{"rendered":"Is anyone collecting data on how many of those that \u201csurvive\u201d are permanently injured?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\" id=\"ac38\"><strong>Question:<\/strong>&nbsp;Well&nbsp;<a href=\"https:\/\/www.nytimes.com\/2020\/06\/04\/opinion\/covid-19-survivors-effects.html\">this opinion<\/a>&nbsp;in the NY Times, \u201cOur Next Crisis Will Be Caring for Survivors of Covid-19\u201d, is really depressing. And my 9\/11 health friend has been pointing this out to me for weeks \u2014 that survival doesn\u2019t mean \u201call better\u201d. Is anyone collecting data on how many of those that \u201csurvive\u201d are permanently injured?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"0516\"><strong>Answer:&nbsp;<\/strong>So true; Survival doesn\u2019t mean \u201call better.\u201d Over the last month or two, there have been more and more news reports on this issue, especially the issue of&nbsp;<a href=\"https:\/\/www.theatlantic.com\/science\/archive\/2020\/04\/life-after-the-icu\/610384\/\">long-term challenges<\/a>&nbsp;experienced by&nbsp;<a href=\"https:\/\/www.npr.org\/sections\/health-shots\/2020\/04\/21\/840343240\/after-the-icu-many-covid-19-survivors-face-a-long-recovery\">patients<\/a>&nbsp;coming off of&nbsp;<a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2020-04-24\/life-after-ventilators-can-be-hell-for-coronavirus-survivors\">ventilators<\/a>&nbsp;and out of the&nbsp;<a href=\"https:\/\/www.newyorker.com\/science\/medical-dispatch\/the-challenges-of-post-covid-19-care\">ICU<\/a>. This&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0048969720325389\">review article<\/a>, recently published in&nbsp;<em>Science of the Total Environment&nbsp;<\/em>(a journal I was not previously familiar with), discusses the need for longitudinal cohort studies to understand the needs of COVID-19 survivors. It also offers a helpful visualization of the ways in which COVID infection could have long-term physical ramifications (<strong>Figure 1<\/strong>). Meanwhile, guidance published by the UK\u2019s National Health Service last week, \u201c<a href=\"https:\/\/www.england.nhs.uk\/coronavirus\/wp-content\/uploads\/sites\/52\/2020\/06\/C0388-after-care-needs-of-inpatients-recovering-from-covid-19-5-june-2020-1.pdf\">After-care needs of in-patients recovering from COVID-19<\/a>\u201d, provides the best synthesis I\u2019ve seen of the ongoing issues and needs of patients who survive COVID-19. For example, the guidance notes that post-intensive care syndrome (PICS), \u201can amalgamation of persistent physical, cognitive and psychological impairments, [has been found to] present in 56% of patients at 12 months following prolonged ventilation.\u201d Check out the guidance for more evidence-informed detail!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"10e2\">Finally, I think you\u2019ll be heartened to know that there are a number of longitudinal cohort studies being planned and currently recruiting study participants to understand long-term effects of COVID among people who recover. Here are a few longitudinal cohort studies in the works:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04411147?term=longitudinal+cohort&amp;cond=COVID&amp;draw=2&amp;rank=2\">A Longitudinal Study of COVID-19 Sequelae and Immunity<\/a>: NIH-planned study that will begin recruitment this month with the aim of enrolling 900 participants who have recovered from COVID-19 to \u201ccharacterize the clinical sequelae of acute infection, characterize the immune response to the virus, and follow the evolution of the immune response over time and determine the extent to which natural immunity is protective against re-infection.\u201d<\/li><li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04393155?term=longitudinal+cohort&amp;cond=COVID&amp;draw=2&amp;rank=5\">Longitudinal COVID-19 Cohort Study<\/a>: University of Vermont and Johns Hopkins Univeristy-planned study that began recruitment last month with the aim of enrolling 225 participants with COVID-19 to \u201clongitudinally follow survivors for 12 months, to investigate short-term and longer-term inflammatory\/immunologic and clinical outcomes during this pandemic.\u201d<\/li><li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04375709?term=longitudinal+cohort&amp;cond=COVID&amp;draw=2&amp;rank=10\">Quality of Life and Physical Performance After Novel Coronavirus Infection<\/a>: Kantonsspital Winterthur (Switzerland)-planned study that began recruitment last month with the aim of enrolling 60 participants with COVID-19 to \u201cobserve the long-term health-related quality of life (HRQOL) and physical performance in individuals hospitalized due to a COVID-19 infection.\u201d<\/li><li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04369807?term=longitudinal+cohort&amp;cond=COVID&amp;draw=3&amp;rank=15\">Mapping Organ Health Following COVID-19 Disease Due to SARS-CoV-2 Infection<\/a>: Mayo Clinic (UK) and Gemini (UK)-planned study that just began recruitment with the aim of enrolling 507 participants with COVID-19 who are recovered or recovering to \u201cmeasure the prevalence of organ volume changes and damage in lungs, heart, kidney, liver, pancreas, spleen as assessed by MRI among those having recovered, or recovering\u201d<\/li><li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04330599?term=longitudinal+cohort&amp;cond=COVID&amp;draw=3&amp;rank=20\">Longitudinal Population-based Observational Study of COVID-19 in the UK Population<\/a>: Queen Mary University of London-led study that should be in the recruitment phase now with the aim of enrolling 12,000 participants who are UK residents age 16+ to \u201c1. Determine risk factors for incident COVID-19 and for adverse outcomes of COVID-19 in the UK population; 2. Characterise the natural history of COVID-19 in the UK population; 3. Evaluate the impact of COVID-19 on the physical and mental health of the UK population; 4. Provide a resource from which to identify potential participants for future clinical trials, and to use data collected as comparison or control data for trial participants who have been randomised to receive one or more interventions.\u201d<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"2a19\"><strong>Figure 1. Potential Biological Impacts of COVID-19&nbsp;<\/strong>(image from&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0048969720325389\">this paper<\/a>)<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/miro.medium.com\/max\/2474\/1%2AiN78UOIKe9QK8X9_PETlyA.png?w=723&#038;ssl=1\" alt=\"Image for post\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Question:&nbsp;Well&nbsp;this opinion&nbsp;in the NY Times, \u201cOur Next Crisis Will Be Caring for Survivors of Covid-19\u201d, is really depressing. And my 9\/11 health friend has been pointing this out to me for weeks \u2014 that survival doesn\u2019t mean \u201call better\u201d. Is anyone collecting data on how many of those that \u201csurvive\u201d are permanently injured? Answer:&nbsp;So true; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":435,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[40,34],"tags":[61],"class_list":["post-434","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-disease-severity","category-symptoms","tag-recovery","fallback-thumbnail"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/covidqanda.org\/wp-content\/uploads\/2020\/11\/June-11.png?fit=1237%2C627&ssl=1","_links":{"self":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=434"}],"version-history":[{"count":1,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/434\/revisions"}],"predecessor-version":[{"id":436,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/434\/revisions\/436"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/media\/435"}],"wp:attachment":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}