{"id":1277,"date":"2021-04-05T08:39:23","date_gmt":"2021-04-05T12:39:23","guid":{"rendered":"https:\/\/covidqanda.org\/?p=1277"},"modified":"2021-04-05T08:39:23","modified_gmt":"2021-04-05T12:39:23","slug":"can-plasma-from-never-infected-vaccinated-people-be-used-for-treatment","status":"publish","type":"post","link":"https:\/\/covidqanda.org\/?p=1277","title":{"rendered":"Can plasma from never-infected vaccinated people be used for treatment?"},"content":{"rendered":"\n

Question:<\/span><\/strong>\u00a0I know that convalescent\u00a0plasma\u00a0can be beneficial treatment\u00a0for some COVID cases.\u00a0 With far more of us vaccinated, can plasma from vaccinated people serve the same purpose?<\/p>\n\n\n\n

Answer:<\/span><\/strong>\u00a0When it comes to using plasma for treatment, the FDA’s Guidelines on Investigational COVID-19 Convalescent Plasma<\/a>\u00a0preclude use of plasma from vaccinated individuals who never contracted COVID.\u00a0 The FDA has several other eligibility criteria, including that the donor’s symptoms must be completely resolved for at least 14 days before donation and the plasma must have high concentration of SARS-specific antibodies. An estimate from one US-based donation center suggests that only 19.5% of plasma donations meet the FDA’s high antibody concentration criteria (see editorial\u00a0published in NEJM<\/em><\/a>). The reason for the focus on previous infection rather than vaccination is that plasma from previously infected\u00a0individuals contains antibodies directly related to their immune response to SARS-CoV-2 infection; these types of antibodies are preferable for treatment purposes.\u00a0<\/p>\n\n\n\n

Regardless, evidence on the effectiveness\u00a0of blood plasma for treatment is mixed.\u00a0The largest meta-analysis to data concluded that “Among patients with COVID-19, treatment with convalescent plasma compared with control was not associated with improved survival or other positive clinical outcomes.” (see study published in JAMA<\/em><\/a>).\u00a0A more recent study suggested that the benefit was greatest when plasma transfusions had high levels of antibodies and were given at early stages of disease (see study from\u00a0NEJM<\/a>)<\/em>.\u00a0 Several researchers suggest that “antibody-rich convalescent plasma from previously infected patients vaccinated with at least one dose of the BNT162b2 vaccine might be more effective than the convalescent plasma from non-vaccinated patients”\u00a0(see recent\u00a0comment from\u00a0Lancet<\/em><\/a>), and the FDA suggests<\/a> that such a hypothesis be tested in the context of a clinical trial.<\/p>\n","protected":false},"excerpt":{"rendered":"

Question:\u00a0I know that convalescent\u00a0plasma\u00a0can be beneficial treatment\u00a0for some COVID cases.\u00a0 With far more of us vaccinated, can plasma from vaccinated people serve the same purpose? Answer:\u00a0When it comes to using plasma for treatment, the FDA’s Guidelines on Investigational COVID-19 Convalescent Plasma\u00a0preclude use of plasma from vaccinated individuals who never contracted COVID.\u00a0 The FDA has several […]<\/p>\n","protected":false},"author":1,"featured_media":1278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[67,64],"tags":[63],"class_list":["post-1277","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment","category-vaccines","tag-blood-type","fallback-thumbnail"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/covidqanda.org\/wp-content\/uploads\/2021\/04\/pexels-photo-1350560.jpeg?fit=1880%2C1253&ssl=1","_links":{"self":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/1277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1277"}],"version-history":[{"count":1,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/1277\/revisions"}],"predecessor-version":[{"id":1279,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/posts\/1277\/revisions\/1279"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=\/wp\/v2\/media\/1278"}],"wp:attachment":[{"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/covidqanda.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}